Trifluoroacetic anhydride → HCID 58464128, compound

HRID 1917536Notes

Reaction equation

HRID 1917536 reaction equation
[OH:1][CH:2]([C:9]([OH:11])=[O:10])[C:3]([CH3:8])([CH3:7])[C:4]([OH:6])=O.FC(F)(F)C(OC(=O)C(F)(F)F)=O>C(Cl)Cl>[OH:1][CH:2]1[C:9](=[O:10])[O:11][C:4](=[O:6])[C:3]1([CH3:7])[CH3:8]

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 4627602Butanedioic acid, 3-hydroxy-2,2-dimethyl-

Product 1

HCID 58464128HCID 58464128, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
2.5 °C

Procedure

(3RS)-3-Hydroxy-2,2-dimethyl-succinic acid [Tetrahedron Letters (2002), 43(52), 9513-9515] (120 mg, 0.74 mmol) was suspended in CH2Cl2 (2 ml) and cooled to 0-5° C. Trifluoroacetic anhydride (260 μl, 1.85 mmol) was added and the reaction mixture stirred for 2 hours at room temperature. The reaction mixture was evaporated to dryness and used without any further purification in the next step.

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. customused without any further purification in the next step

Sources & evidence

ORD record
ord-54148b66e452427ea4f60509dd384a6b
Source dataset
uspto-grants-2013_12
Patent number
US08618296B2

Reaction notes

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