Tetrabutylammonium Fluoride → HCID 58464054, compound

HRID 1917538Notes

Reaction equation

C([Si](C1C=CC=CC=1)(C1C=CC=CC=1)[O:6][CH:7]1[C:11]([CH3:13])([CH3:12])[CH2:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([C:20]#[C:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:16][N:15]=2)[C:8]1=[O:28])(C)(C)C.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>C1COCC1>[OH:6][CH:7]1[C:11]([CH3:13])([CH3:12])[CH2:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([C:20]#[C:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:16][N:15]=2)[C:8]1=[O:28]

Participants

Conditions

Temperature: 60 °C

Procedure

(100 mg, 0.18 mmol) (3RS)-3-(tert-Butyl-diphenyl-silanyloxy)-4,4-dimethyl-1-(5-phenylethynyl-pyridin-2-yl)-pyrrolidin-2-one (Example 14, step 6) was dissolved in THF (1 ml) and TBAF (1M in THF) (184 μl, 0.184) was added drop wise at room temperature. The mixture was stirred for 1 hr at 60° C. The reaction mixture was extracted with sat. NaHCO3-solution and two times EtOAc. The organic layers were extracted with water, dried over Na2SO4, filtered and evaporated to dryness. The crude material was purified by flash chromatography on silica gel (20 gr, ethyl acetate/heptane gradient, 0:100 to 100:0). The desired (3RS)-3-hydroxy-4,4-dimethyl-1-(5-phenylethynyl-pyridin-2-yl)-pyrrolidin-2-one (44 mg, 78% yield) was obtained as a white solid, MS: m/e=307.3 (M+H+).

Workup

extractionThe reaction mixture was extracted with sat. NaHCO3-solution and two times EtOAc
extractionThe organic layers were extracted with water
dry with materialdried over Na2SO4
filtrationfiltered
customevaporated to dryness
customThe crude material was purified by flash chromatography on silica gel (20 gr, ethyl acetate/heptane gradient, 0:100 to 100:0)

Sources & evidence

ORD record: ord-d850d0276492427d9bda2ac871fa8e81
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618296B2

Reaction notes

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