p-Chlorophenacyl bromide → HCID 86659071, compound

HRID 1917598Notes

Reaction equation

HRID 1917598 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[Br:10][CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)=[O:13]>C(#N)C>[Br-:10].[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:12](=[O:13])[CH2:11][N+:7]2[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 68303p-Chlorophenacyl bromideHCID 696744-Isopropylpyridine

Product 1

HCID 86659071HCID 86659071, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
23 °C

Procedure

To a solution of 4-isopropylpyridine (3.12 g, 25.7 mmol) in acetonitrile (25 mL) is added 2-bromo-4′-chloro-acetophenone (6.01 g, 25.7 mmol). The mixture is stirred at 23° C. overnight then the resulting precipitate is filtered, collected, and dried to afford the title intermediate (7.10 g, 78%).

Workup

  1. filtrationthe resulting precipitate is filtered
  2. customcollected
  3. customdried

Sources & evidence

ORD record
ord-a6e9c2cd01284b138aecab870f1b0c3d
Source dataset
uspto-grants-2013_12
Patent number
US08618300B2

Reaction notes

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