4-Chloro-5-methylquinazoline → 1-(5-Tert-butyl isoxazol-3-yl)-3-(3-(5-methylquinazolin-4-yloxy)phenyl)urea

HRID 1917629Notes

Reaction equation

HRID 1917629 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=2)=[O:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][C:30]=2[CH3:32])[N:25]=[CH:24][N:23]=1>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:22]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][C:30]=4[CH3:32])[N:25]=[CH:24][N:23]=3)[CH:15]=2)=[O:12])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 134955764-Chloro-5-methylquinazolineHCID 668765951-(5-Tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea

Product 1

HCID 442431781-(5-Tert-butyl isoxazol-3-yl)-3-(3-(5-methylquinazolin-4-yloxy)phenyl)urea

Procedure

To 1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea from Example 1A (83 mg, 0.3 mmol) was added 4-chloro-5-methylquinazoline from the previous step (53 mg, 0.3 mmol) using the procedure described in Example 1B Step 1, to afford the title compound.

Sources & evidence

ORD record
ord-c0086a176f2a43b2b7e105008dbe04ad
Source dataset
uspto-grants-2013_12
Patent number
US08618289B2

Reaction notes

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