HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-5-methylquinazoline → 1-(5-Tert-butyl isoxazol-3-yl)-3-(3-(5-methylquinazolin-4-yloxy)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-5-methylquinazoline | HCID 13495576 | — |
| Reactant | 1-(5-Tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea | HCID 66876595 | — |
| Product | 1-(5-Tert-butyl isoxazol-3-yl)-3-(3-(5-methylquinazolin-4-yloxy)phenyl)urea | HCID 44243178 | — |
Reaction Steps
To 1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea from Example 1A (83 mg, 0.3 mmol) was added 4-chloro-5-methylquinazoline from the previous step (53 mg, 0.3 mmol) using the procedure described in Example 1B Step 1, to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618289B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-c0086a176f2a43b2b7e105008dbe04ad |
| Source note | uspto-grants-2013_12 |