Ammonia → 2-(2-cyclopentyl-1,3-dioxolan-2-yl)-N'-hydroxyacetimidamide

HRID 1917881ノート

反応式

HRID 1917881 の反応式
[CH:1]1([C:6]2([CH2:11][C:12]#[N:13])[O:10][CH2:9][CH2:8][O:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[NH2:15][OH:16].N>>[CH:1]1([C:6]2([CH2:11][C:12](=[N:15][OH:16])[NH2:13])[O:10][CH2:9][CH2:8][O:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

4

反応物 3

HCID 222AmmoniaHCID 443297Hydroxyamine hydrochlorideHCID 668766282-(2-Cyclopentyl-1,3-dioxolan-2-yl)acetonitrile

生成物 1

HCID 866535152-(2-cyclopentyl-1,3-dioxolan-2-yl)-N'-hydroxyacetimidamide

実験手順

According to the procedure described in Example 133A Step 3, 2-(2-cyclopentyl-1,3-dioxolan-2-yl)acetonitrile (1.5 g, 8.3 mmol) was reacted with hydroxylamine hydrochloride (3.17 g, 45.5 mmol) and liquid ammonia (7.8 mL, 7N in methanol), to afford 2-(2-cyclopentyl-1,3-dioxolan-2-yl)-N′-hydroxyacetimidamide, which was used directly in the next step without further purification. 1H NMR (300 MHz, CDCl3) δ 5.11 (bs, 2H), 4.20-3.95 (m, 4H), 2.38 (s, 2H), 2.33-2.22 (m, 1H), 1.73-1.41 (m, 8H); LC-MS (ESI) m/z 215 (M+H)+

出典と根拠

ORDレコード
ord-d6e836c8e6494ab9afe86281ac647806
出典データセット
uspto-grants-2013_12
特許番号
US08618289B2

反応ノート

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