化工社化工社 化学情報印刷レポート · 研究参考用
Phenyl chloroformate → phenyl 3-tert-butyl-1-(pyridin-3-yl)-1H-pyrazol-5-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenyl chloroformate | HCID 15891 | — |
| 反応物 | 3-(Tert-butyl)-1-(3-pyridyl)pyrazole-5-amine | HCID 46196775 | — |
| 生成物 | phenyl 3-tert-butyl-1-(pyridin-3-yl)-1H-pyrazol-5-ylcarbamate | HCID 66876858 | 95.1% |
反応手順
Following the procedure in Example 118A, 3-tert-butyl-1-(pyridin-3-yl)-1H-pyrazol-5-amine (665 mg, 3.08 mmol) and phenyl chloroformate (705 mg, 4.5 mmol) were reacted to give phenyl 3-tert-butyl-1-(pyridin-3-yl)-1H-pyrazol-5-ylcarbamate (984 mg, 2.93 mmol, 95%). 1H NMR (300 MHz, DMSO-d6) δ 7.42-7.39 (m, 3H), 7.30-7.26 (m, 5H), 6.85 (t, 1H), 6.82 (d, 2H), 1.21 (s, 9H); LC-MS (ESI) m/z 337 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08618289B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-83adefab3bde4da391e031162acdf49e |
| 出典メモ | uspto-grants-2013_12 |