HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-(Benzofuran-2-carboxamido)-2-(5-methoxypyrazin-2-yl)thiophene-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 4-(benzofuran-2-carboxamido)-2-(5-methoxypyrazin-2-yl)thiophene-3-carboxylate | HCID 67052227 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 4-(Benzofuran-2-carboxamido)-2-(5-methoxypyrazin-2-yl)thiophene-3-carboxylic acid | HCID 67052363 | — |
Reaction Steps
The ester 161 and lithium hydroxide in tetrahydrofuran: methanol:water (3:2:1) is stirred at room temperature for 4 h. The mixture is diluted with DMF and purified by HPLC to provide 162.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618307B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-327f33353a5e41e2a92697de9416d73c |
| Source note | uspto-grants-2013_12 |