HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-(4-Methylbenzamido)-2-p-tolylthiophene-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 4-(4-methylbenzamido)-2-p-tolylthiophene-3-carboxylate | HCID 67052278 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 4-(4-Methylbenzamido)-2-p-tolylthiophene-3-carboxylic acid | HCID 67052426 | — |
Reaction Steps
The ester 180 and lithium hydroxide in tetrahydrofuran: methanol:water (3:2:1) is stirred at room temperature for 4 h. The mixture is diluted with DMF and purified by HPLC to provide 181.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618307B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-df03c282fa984dfc8f8ff7473787c1ef |
| Source note | uspto-grants-2013_12 |