Hydrochloric Acid → HCID 178440085, compound

Participants

Reaction Conditions

Reaction Steps

100 ml of 10% aqueous sodium hydroxide solution were added into a solution of 20 grams of ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate in 200 ml of acetone. The mixture was refluxed for 3 hours. After cooled to 10° C., pH of the reactant was adjusted to 6.4 using concentrated hydrochloric acid, solids precipitated. The precipitation was filtered, collected, washed with water, then dried to give 16.7 grams of whitish solid 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylic acid (formula III), resulting in a yield of 95%.

Provenance & Evidence