Hydrochloric Acid → HCID 178440085, compound

HRID 1918239Notes

Reaction equation

HRID 1918239 reaction equation
[OH-].[Na+].[OH:3][C:4]([C:7]1[N:8]=[C:9]([CH2:17][CH2:18][CH3:19])[NH:10][C:11]=1[C:12]([O:14]CC)=[O:13])([CH3:6])[CH3:5].Cl>CC(C)=O>[OH:3][C:4]([C:7]1[N:8]=[C:9]([CH2:17][CH2:18][CH3:19])[NH:10][C:11]=1[C:12]([OH:14])=[O:13])([CH3:6])[CH3:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178440079HCID 178440079, compound

Product 1

HCID 178440085HCID 178440085, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
10 °C

Procedure

100 ml of 10% aqueous sodium hydroxide solution were added into a solution of 20 grams of ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate in 200 ml of acetone. The mixture was refluxed for 3 hours. After cooled to 10° C., pH of the reactant was adjusted to 6.4 using concentrated hydrochloric acid, solids precipitated. The precipitation was filtered, collected, washed with water, then dried to give 16.7 grams of whitish solid 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylic acid (formula III), resulting in a yield of 95%.

Workup

  1. temperatureThe mixture was refluxed for 3 hours
  2. customprecipitated
  3. customThe precipitation
  4. filtrationwas filtered
  5. customcollected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-5d116fe53abd4d1eb83edd458a2f642d
Source dataset
uspto-grants-2013_12
Patent number
US08618308B2

Reaction notes

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