HRID1918242

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222656

(2S)-2-Hydroxybutanedioic acid

C4H6O5

$结构：CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C$

HCID5329102

Sunitinib

C22H27FN4O2

PRODUCTS

生成物

$结构：CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C.O=C(O)C[C@H](O)C(=O)O$

HCID6456015

Sunitinib malate

C26H33FN4O7

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31272

Butyl acetate

C6H12O2

PROCEDURE

实验过程

Sunitinib base (300 mg), L-malic acid (101 mg) and butyl acetate (10 ml) were heated to reflux 10 min. The suspension was allowed to cool to RT, filtered, washed with n-hexane and dried on air.

WORKUP

后处理

temperatureto reflux 10 min
filtrationfiltered
washwashed with n-hexane
customdried on air

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-140a84110053429bad95108b962e12b4
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08618309B2
来源说明: uspto-grants-2013_12

反应 SMILES

[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[C@H:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32]>C(OCCCC)(=O)C>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]