HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylbenzeneethanol → 1-[2-Fluoro-4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-cycloheptanecarboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylbenzeneethanol | HCID 74648 | — |
| Reactant | Methyl 1-aminocycloheptane-1-carboxylate hydrochloride | HCID 42614177 | — |
| Reactant | Methyl 2-fluoro-3-hydroxy-4-methoxybenzoate | HCID 67076493 | — |
| Product | 1-[2-Fluoro-4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-cycloheptanecarboxylic Acid | HCID 67170338 | — |
Reaction Steps
2-Fluoro-3-hydroxy-4-methoxybenzoic acid methyl ester was coupled to 2-m-tolylethanol, the intermediate hydrolyzed, coupled to 1-amino-cycloheptanecarboxylic acid methyl ester hydrochloride and the obtained ester hydrolyzed in analogy to steps 1 to 4 of example 1 to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618304B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-596f8c1e4e1b4d22bd58f175ed19fd29 |
| Source note | uspto-grants-2013_12 |