Sodium Hydroxide → 1-[(3'-Chloro-2',6'-difluoro-6,4'-dimethoxy-biphenyl-3-carbonyl)-amino]-4-methyl-cyclohexanecarboxylic Acid
Reaktionsgleichung
C[O:2][C:3]([C:5]1([NH:12][C:13]([C:15]2[CH:16]=[C:17]([C:23]3[C:28]([F:29])=[CH:27][C:26]([O:30][CH3:31])=[C:25]([Cl:32])[C:24]=3[F:33])[C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)=[O:14])[CH2:10][CH2:9][CH:8]([CH3:11])[CH2:7][CH2:6]1)=[O:4].[OH-].[Na+].O1CCOCC1>O>[Cl:32][C:25]1[C:24]([F:33])=[C:23]([C:17]2[C:18]([O:21][CH3:22])=[CH:19][CH:20]=[C:15]([C:13]([NH:12][C:5]3([C:3]([OH:4])=[O:2])[CH2:10][CH2:9][CH:8]([CH3:11])[CH2:7][CH2:6]3)=[O:14])[CH:16]=2)[C:28]([F:29])=[CH:27][C:26]=1[O:30][CH3:31]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
150 mg of 1-[(3′-Chloro-2′,6′-difluoro-6,4′-dimethoxy-biphenyl-3-carbonyl)-amino]-4-methyl-cyclohexanecarboxylic acid methyl ester and 25 mg NaOH were dissoled using 5 ml of dioxane and 0.5 ml of water. The mixture was stirred at 80° C. for 6 h. Then, 15 ml of water were added, the dioxane evaporated and acidified to pH=3 using aqueous NaHSO4-solution. The mixture was stirred for 30 minutes at room temperature. The product was then isolated by filtration and dried in vacuo to yield 110 mg of the title compound.
Aufarbeitung
- customthe dioxane evaporated
- stirringThe mixture was stirred for 30 minutes at room temperature
- customThe product was then isolated by filtration
- customdried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-0fbc3a2cc2a144c69254a810e2a4243b
- Quelldatensatz
- uspto-grants-2013_12
- Patentnummer
- US08618304B2
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