反应详情

5-Chloro-2′-methoxy-2,4′-bipyridine (810 mg, 3.67 mmol) was stirred in concentrated hydrochloric acid (10 mL) at 120° C. for 18 h and then concentrated. The residue was adjusted to pH 8 with 6 N NaOH and the solids were filtered off, washed with water and dried under vacuum to provide the title compound (617 mg, 81%) as a white solid: 1H NMR (300 MHz, DMSO-d6) δ 11.73 (s, 1H), 8.75 (s, 1H), 8.06 (s, 2H), 7.49 (d, J=6.8 Hz, 1H), 7.00 (s, 1H), 6.85-6.84 (dd, J=6.8, 1.7 Hz, 1H).

1. concentrationconcentrated
2. filtrationthe solids were filtered off
3. washwashed with water
4. customdried under vacuum