反应详情

温度

70 °C

A mixture of 3-(2-bromoethyl)-6-chloro-5-methyl-2-(triethylsilyl)-1H-indole (0.725 g; 1.87 mmol) and sodium azide (0.365 g; 5.62 mmol) in DMF (8 mL) was stirred at 70° C. for 4 hours and concentrated under reduced pressure. The residue was diluted in ethyl acetate, washed with brine, dried and concentrated under reduced pressure to afford 0.690 g (quantitative yield) of the title compound as a brown oil.

1. concentrationconcentrated under reduced pressure
2. additionThe residue was diluted in ethyl acetate
3. washwashed with brine
4. customdried
5. concentrationconcentrated under reduced pressure