HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1918626Generated: November 2, 2026
Sodium Azide → 3-(2-azidoethyl)-2-(triethylsilyl)-1H-indole-5-carbonitrile
https://huagongshe.com/reaction/1918626
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 3-(2-bromoethyl)-2-(triethylsilyl)-1H-indole-5-carbonitrile | HCID 66831928 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2-azidoethyl)-2-(triethylsilyl)-1H-indole-5-carbonitrile | HCID 86663838 | — |
Reaction Steps
A mixture of 3-(2-bromoethyl)-2-(triethylsilyl)-1H-indole-5-carbonitrile (0.906 g; 2.49 mmol) and sodium azide (0.486 g; 7.48 mmol) in DMF (7 mL) was stirred at 70° C. for 4 hours and concentrated under reduced pressure. The residue was diluted in ethyl acetate, washed with brine, dried and concentrated under reduced pressure to yield 0.900 g (quantitative) of the title compound as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618138B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-f5101ed3b33346a1a3a6376b2cdaf3a0 |
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| Source note | uspto-grants-2013_12 |
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