反应详情

温度

70 °C

A mixture of 3-(2-bromoethyl)-2-(triethylsilyl)-1H-indole-5-carbonitrile (0.906 g; 2.49 mmol) and sodium azide (0.486 g; 7.48 mmol) in DMF (7 mL) was stirred at 70° C. for 4 hours and concentrated under reduced pressure. The residue was diluted in ethyl acetate, washed with brine, dried and concentrated under reduced pressure to yield 0.900 g (quantitative) of the title compound as a brown oil.

1. concentrationconcentrated under reduced pressure
2. additionThe residue was diluted in ethyl acetate
3. washwashed with brine
4. customdried
5. concentrationconcentrated under reduced pressure