HRID1918858

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(=O)OCc1c(-c2cn(C)c(=O)c(Nc3ccc4c(c3)CCN(C(=O)OC(C)(C)C)C4)n2)cc(F)cc1N1CCn2c(cc3c2CCCC3)C1=O

HCID67016272

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCc1c(-c2cn(C)c(=O)c(Nc3ccc4c(c3)CCNC4)n2)cc(F)cc1N1CCn2c(cc3c2CCCC3)C1=O

HCID67016210

未命名化合物

收率 99.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

To the solution of 129a (360 mg 0.51 mmol) in DCM (30 mL) was added 3M HCl in dioxane (8 mL) at room temperature. The mixture was stirred at room temperature for 5 h. After the reaction was completed, the solvent was removed at reduced pressure to afford 129b as a yellow solid (310 mg, 99%).

WORKUP

后处理

customthe solvent was removed at reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1b150895eadc469fb1bee388cbe83f08
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08618107B2
来源说明: uspto-grants-2013_12

反应 SMILES

C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([NH:18][C:19]3[C:24](=[O:25])[N:23]([CH3:26])[CH:22]=[C:21]([C:27]4[CH:32]=[C:31]([F:33])[CH:30]=[C:29]([N:34]5[CH2:46][CH2:45][N:37]6[C:38]7[CH2:39][CH2:40][CH2:41][CH2:42][C:43]=7[CH:44]=[C:36]6[C:35]5=[O:47])[C:28]=4[CH2:48][O:49][C:50](=[O:52])[CH3:51])[N:20]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>C(Cl)Cl.O1CCOCC1>[C:50]([O:49][CH2:48][C:28]1[C:29]([N:34]2[CH2:46][CH2:45][N:37]3[C:38]4[CH2:39][CH2:40][CH2:41][CH2:42][C:43]=4[CH:44]=[C:36]3[C:35]2=[O:47])=[CH:30][C:31]([F:33])=[CH:32][C:27]=1[C:21]1[N:20]=[C:19]([NH:18][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:17][CH2:16]3)[C:24](=[O:25])[N:23]([CH3:26])[CH:22]=1)(=[O:52])[CH3:51]