反应详情

温度

30 °C

A mixture of 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole 101c (4 g, 12.9 mmol) and cyclopropanamine (7.35 g, 129 mmol) in THF (40 mL) was stirred at 30° C. overnight. After the completion of the reaction, the mixture was filtered off and the solid was washed with THF (100 mL). The filtrate was concentrated under reduced pressure to give 135a (2.68 g, 99%). MS: [M+H]+ 209.

1. customAfter the completion of the reaction
2. filtrationthe mixture was filtered off
3. washthe solid was washed with THF (100 mL)
4. concentrationThe filtrate was concentrated under reduced pressure