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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1918948Generated: November 1, 2026

Methanesulfonyl chloride → (6-(6-Chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)methyl methanesulfonate

https://huagongshe.com/reaction/1918948

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonyl chlorideHCID 31297—
ReactantDiisopropylethylamineHCID 81531—
Reactant6-Chloro-4-(5-(hydroxymethyl)pyridin-2-ylamino)-2-methylpyridazin-3(2H)-oneHCID 58043762—
SolventDichloromethaneHCID 6344—
Product(6-(6-Chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)methyl methanesulfonateHCID 58043865—

Reaction Steps

Intermediate 180b was treated with methanesulfonyl chloride and diisopropylethylamine in methylene chloride at 0° C. to give 180c.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08618107B2
Source datasetuspto-grants-2013_12
ORD IDord-baa9a108b8414a8f882b6327ae02b915
Source noteuspto-grants-2013_12