Methanesulfonyl chloride → (6-(6-Chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)methyl methanesulfonate

HRID 1918948Notes

Reaction equation

HRID 1918948 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][N:12]=2)[C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21].C(N(C(C)C)CC)(C)C>C(Cl)Cl>[CH3:19][S:20]([O:18][CH2:17][C:14]1[CH:13]=[N:12][C:11]([NH:10][C:4]2[C:5](=[O:9])[N:6]([CH3:8])[N:7]=[C:2]([Cl:1])[CH:3]=2)=[CH:16][CH:15]=1)(=[O:22])=[O:21]

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 580437626-Chloro-4-(5-(hydroxymethyl)pyridin-2-ylamino)-2-methylpyridazin-3(2H)-one

Product 1

HCID 58043865(6-(6-Chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)methyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Intermediate 180b was treated with methanesulfonyl chloride and diisopropylethylamine in methylene chloride at 0° C. to give 180c.

Sources & evidence

ORD record
ord-baa9a108b8414a8f882b6327ae02b915
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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