참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 6-Nitropyridin-3-ol | HCID 2762857 | — |
| 반응물 | Tert-butyl 3-iodoazetidine-1-carboxylate | HCID 11000522 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | tert-Butyl 3-(6-Nitropyridin-3-yloxy)azetidine-1-carboxylate | HCID 58043652 | 59% |
반응 단계
A mixture of 199a (2.24 g, 7.9 mmol), 6-nitropyridin-3-ol (1 g, 7.2 mmol) and Cs2CO3 (2.6 g, 7.9 mmol) in DMF (8 mL) was heated at 125° C. in a sealed tube for overnight. The mixture was filtered off and washed with ethyl acetate (20 mL×2). The filtrate was evaporated in vacuo and the residue was purified on reverse phase Combi-flash to give 199b (1.25 g, 59%). MS: [M+H]+ 296.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08618107B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_12 |
|---|
| ORD ID | ord-3b479691a5c04ba6bb467ac3ca4fd31b |
|---|
| 출처 메모 | uspto-grants-2013_12 |
|---|
