反应详情

温度

125 °C

A mixture of 199a (2.24 g, 7.9 mmol), 6-nitropyridin-3-ol (1 g, 7.2 mmol) and Cs2CO3 (2.6 g, 7.9 mmol) in DMF (8 mL) was heated at 125° C. in a sealed tube for overnight. The mixture was filtered off and washed with ethyl acetate (20 mL×2). The filtrate was evaporated in vacuo and the residue was purified on reverse phase Combi-flash to give 199b (1.25 g, 59%). MS: [M+H]+ 296.

1. filtrationThe mixture was filtered off
2. washwashed with ethyl acetate (20 mL×2)
3. customThe filtrate was evaporated in vacuo
4. customthe residue was purified on reverse phase Combi-flash