Hydrazine hydrate (1:1) → HCID 19616674, compound

HRID 1918988Notes

Reaction equation

HRID 1918988 reaction equation
[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][N:11]2C(=O)C3C(=CC=CC=3)C2=O)[N:5]=1)([O-:3])=[O:2].O.NN>C(O)C>[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][NH2:11])[N:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58044294HCID 58044294, compound

Product 1

HCID 19616674HCID 19616674, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 206a (2.0 g, 7.0 mmol) in ethanol (30 mL) was added hydrazine hydrate (1 mL, 21 mmol) and the mixture was stirred at room temperature for 3 hours. The mixture was evaporated and the residue was purified by silica-gel eluting with 10:1 methylene chloride/methanol to give 206b as a white solid (0.8 g, 80%). MS: (M+H)+ 157.

Workup

  1. customThe mixture was evaporated
  2. customthe residue was purified by silica-gel
  3. washeluting with 10:1 methylene chloride/methanol

Sources & evidence

ORD record
ord-09813d0c546c4ed2b2c8ac1168de0ecb
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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