4-(6-Nitropyridin-3-yl)morpholine → 5-Morpholinopyridin-2-amine

HRID 1919057Notes

Reaction equation

HRID 1919057 reaction equation
NC1N=CC(N2CCN(C(OC(C)(C)C)=O)CC2)=CC=1.[N+:21]([C:24]1[N:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[CH:26][CH:25]=1)([O-])=O>>[O:33]1[CH2:34][CH2:35][N:30]([C:27]2[CH:26]=[CH:25][C:24]([NH2:21])=[N:29][CH:28]=2)[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 29279734-(6-Nitropyridin-3-yl)morpholineHCID 11737525tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

Product 1

HCID 113673465-Morpholinopyridin-2-amine

Procedure

Following the procedures as described for 188b and starting with 1 g of 4-(6-nitropyridin-3-yl)morpholine, 255b was obtained as a yellow solid (840 mg, 98%). MS: [M+H]+ 210

Sources & evidence

ORD record
ord-0a127c7091ac4e5aa569bd675096cb9b
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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