Hydrochloric Acid → HCID 58044158, compound

HRID 1919063Notes

Reaction equation

HRID 1919063 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[CH2:17][NH:16][CH2:15][CH2:14]3)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58044147HCID 58044147, compound

Product 1

HCID 58044158HCID 58044158, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Compound 258a (2.18 g, 5 mmol) was suspended in dioxane (10 mL). Saturated hydrogen chloride in dioxane (20 mL) was added dropwise. The reaction mixture was stirred for 20 minutes and concentrated under reduced pressure to afford 258b, which was used without further purification in the next step. LC/MS: m/z 335 (M+H)+

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-a09a2d012982485ca52beb8c0917c1a8
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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