p-Fluoronitrobenzene → 1-Boc-4-(4-Nitrophenyl)piperazine

HRID 1919121Notes

Reaction equation

HRID 1919121 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[C:11]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:21]2[CH2:20][CH2:19][N:18]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:23][CH2:22]2)=[CH:3][CH:4]=1)([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 33806961-Boc-4-(4-Nitrophenyl)piperazineYield 51%

Procedure

Following Example 188a, 1-fluoro-4-nitrobenzene (2.8 g, 20 mmol) and N-Boc-piperazine (11 g, 60 mmol) were reacted to give 327a as a yellow solid (3 g, 51%). MS: [M+H]+ 308.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3a52baefa42f4fcaa6113d0732ae41e4
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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