HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluoronitrobenzene → 1-Boc-4-(4-Nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Product | 1-Boc-4-(4-Nitrophenyl)piperazine | HCID 3380696 | 51% |
Reaction Steps
Following Example 188a, 1-fluoro-4-nitrobenzene (2.8 g, 20 mmol) and N-Boc-piperazine (11 g, 60 mmol) were reacted to give 327a as a yellow solid (3 g, 51%). MS: [M+H]+ 308.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618107B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-3a52baefa42f4fcaa6113d0732ae41e4 |
| Source note | uspto-grants-2013_12 |