tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate → HCID 58043728, compound

HRID 1919122Notes

Reaction equation

HRID 1919122 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Br[C:22]1[C:23](=[O:30])[N:24]([CH3:29])[CH:25]=[C:26]([Br:28])[N:27]=1>>[Br:28][C:26]1[N:27]=[C:22]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([N:8]3[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]3)=[CH:4][CH:3]=2)[C:23](=[O:30])[N:24]([CH3:29])[CH:25]=1

Participants

3

Reactant 2

HCID 11011301tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylateHCID 130629693,5-Dibromo-1-methyl-1H-pyrazin-2-one

Product 1

HCID 58043728HCID 58043728, compoundYield 68%

Procedure

Following Example 188c, 327b (2.6 g, 9.4 mmol) and 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.5 g, 9.4 mmol) were reacted to give 327c as a yellow solid (2.96 g, 68%). MS: [M+H]+ 464.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-567a6c5fd8c04d60a497922b311ad841
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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