Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1919139생성일: 2026년 10월 26일
Hydrochloric Acid → 1-(6-(5-Bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)pyridin-3-yl)piperazin-2-one
https://huagongshe.com/reaction/1919139
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Tert-Butyl 4-(6-(5-Bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)pyridin-3-yl)-3-oxopiperazine-1-carboxylate | HCID 58043897 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-(6-(5-Bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)pyridin-3-yl)piperazin-2-one | HCID 67016254 | 90% |
반응 단계
A 50-mL round-bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with HCl in 1,4-dioxane (20 mL) and 332d (706 mg, 1.47 mmol). The mixture was stirred for at 65° C. for 6 h. It was then concentrated under reduced pressure to afford 332e as a yellow solid (500 mg, 90%). MS: [M+H]+ 379.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08618107B2 |
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| 출처 데이터셋 | uspto-grants-2013_12 |
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| ORD ID | ord-46f3c68dd21b4dfa976b1b466a586924 |
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| 출처 메모 | uspto-grants-2013_12 |
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