4-Benzyl-2-(fluoromethyl)-1-methylpiperazine → 2-(Fluoromethyl)-1-methylpiperazine
Reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH:10]([CH2:15][F:16])[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[F:16][CH2:15][CH:10]1[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[CH3:14]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 25 °C
Procedure
A 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with 336c (3.0 g, 13.5 mmol), methanol (80 mL), and Pd/C (10%) (300 mg). The reaction mixture was stirred at 25° C. under H2 for 15 h. After the reaction was finished, it was filtered and concentrated to afford 336d as a yellow oil (1.6 g, 90%).
Workup
- customA 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer
- filtrationit was filtered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-ba608b65edc84f96b6099de26311cc9e
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08618107B2
Reaction notes
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