HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1919157Generated: November 1, 2026
4-Benzyl-2-(fluoromethyl)-1-methylpiperazine → 2-(Fluoromethyl)-1-methylpiperazine
https://huagongshe.com/reaction/1919157
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Benzyl-2-(fluoromethyl)-1-methylpiperazine | HCID 19777258 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Fluoromethyl)-1-methylpiperazine | HCID 19777270 | 90% |
Reaction Steps
A 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with 336c (3.0 g, 13.5 mmol), methanol (80 mL), and Pd/C (10%) (300 mg). The reaction mixture was stirred at 25° C. under H2 for 15 h. After the reaction was finished, it was filtered and concentrated to afford 336d as a yellow oil (1.6 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618107B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-ba608b65edc84f96b6099de26311cc9e |
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| Source note | uspto-grants-2013_12 |
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