Acetone Cyanohydrin → HCID 28702592, compound

HRID 1919294Notes

Reaction equation

HRID 1919294 reaction equation
[CH3:1][C:2]([CH3:6])(O)[C:3]#[N:4].[NH2:7][CH2:8][CH2:9][CH2:10][OH:11]>>[OH:11][CH2:10][CH2:9][CH2:8][NH:7][C:2]([CH3:6])([CH3:1])[C:3]#[N:4]

Participants

3

Reactant 2

HCID 6406Acetone CyanohydrinHCID 90863-Amino-1-propanol

Product 1

HCID 28702592HCID 28702592, compoundYield 71%

Procedure

To a neat solution of acetone cyanohydrin (930 mg, 10.9 mmol) at 0° C. was slowly added the 3-amino-1-propanol (861 mg, 11.5 mmol). The resulting solution was stirred at room temperature for 3 hrs and then evaporated under reduce pressure to give the desired compound 3 (1.1 g, 71%) which was directly used for the next step without purification.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-3f5f671d07544fb392aae46bcc0da363
Source dataset
uspto-grants-2012_05
Patent number
US08168627B2

Reaction notes

Loading…