Morpholine → 5-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine

HRID 1919352Notes

Reaction equation

HRID 1919352 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:10]=[C:9]([CH3:11])[S:8][C:6]=2[N:7]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>CO>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[N:10]=[C:9]([CH3:11])[S:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 3456395,7-Dichloro-2-methylthiazolo[5,4-d]pyrimidine

Product 1

HCID 582349395-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidineYield 89%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 5,7-dichloro-2-methyl-thiazolo[5,4-d]pyrimidine (4.1 g, 18.72 mmol) in MeOH (100 mL) was added morpholine (3.26 mL, 37.44 mmol) at 0° C. and the mixture stirred at 0° C. for 30 minutes. The resultant precipitate was collected by filtration and dried in vacuo at 40° C. to give the title compound as a cream solid (4.42 g, 89%).

Workup

  1. filtrationThe resultant precipitate was collected by filtration
  2. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-8bfdfce6f76543d5a65efc5b5be299d2
Source dataset
uspto-grants-2012_05
Patent number
US08168633B2

Reaction notes

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