HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1919352Generated: October 30, 2026
Morpholine → 5-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine
https://huagongshe.com/reaction/1919352
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 5,7-Dichloro-2-methylthiazolo[5,4-d]pyrimidine | HCID 345639 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine | HCID 58234939 | 89% |
Reaction Steps
To a solution of 5,7-dichloro-2-methyl-thiazolo[5,4-d]pyrimidine (4.1 g, 18.72 mmol) in MeOH (100 mL) was added morpholine (3.26 mL, 37.44 mmol) at 0° C. and the mixture stirred at 0° C. for 30 minutes. The resultant precipitate was collected by filtration and dried in vacuo at 40° C. to give the title compound as a cream solid (4.42 g, 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08168633B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-8bfdfce6f76543d5a65efc5b5be299d2 |
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| Source note | uspto-grants-2012_05 |
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