2-Methyl-2-(piperazin-1-yl)propanamide → 2-[4-(5-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidin-2-ylmethyl)piperazin-1-yl]isobutyramide

HRID 1919390Notes

Reaction equation

HRID 1919390 reaction equation
N1(C2CC[N:8]([CH2:11][C:12]3[S:13][C:14]4[N:15]=[C:16]([Cl:27])[N:17]=[C:18]([N:21]5[CH2:26][CH2:25][O:24][CH2:23][CH2:22]5)[C:19]=4[N:20]=3)[CH2:7]C2)CCC1.[N:28]1([C:34]([CH3:39])([CH3:38])[C:35]([NH2:37])=[O:36])[CH2:33]CN[CH2:30][CH2:29]1>>[Cl:27][C:16]1[N:17]=[C:18]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[C:19]2[N:20]=[C:12]([CH2:11][N:8]3[CH2:30][CH2:29][N:28]([C:34]([CH3:39])([CH3:38])[C:35]([NH2:37])=[O:36])[CH2:33][CH2:7]3)[S:13][C:14]=2[N:15]=1

Participants

3

Reactant 2

HCID 217488412-Methyl-2-(piperazin-1-yl)propanamideHCID 582349332-(4-Azetidin-1-ylpiperidin-1-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine

Product 1

HCID 582349642-[4-(5-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidin-2-ylmethyl)piperazin-1-yl]isobutyramide

Procedure

Prepared according to the method used in the preparation of 2-(4-azetidin-1-ylpiperidin-1-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine using 2-piperazin-1-ylisobutyramide in place of 4-azetidin-1-ylpiperidine. The title compound was obtained as a white solid (70 mg, 46%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5e36d18581bc4f3d955cab9c71ec807f
Source dataset
uspto-grants-2012_05
Patent number
US08168633B2

Reaction notes

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