HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-2-(piperazin-1-yl)propanamide → 2-[4-(5-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidin-2-ylmethyl)piperazin-1-yl]isobutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-2-(piperazin-1-yl)propanamide | HCID 21748841 | — |
| Reactant | 2-(4-Azetidin-1-ylpiperidin-1-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine | HCID 58234933 | — |
| Product | 2-[4-(5-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidin-2-ylmethyl)piperazin-1-yl]isobutyramide | HCID 58234964 | — |
Reaction Steps
Prepared according to the method used in the preparation of 2-(4-azetidin-1-ylpiperidin-1-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine using 2-piperazin-1-ylisobutyramide in place of 4-azetidin-1-ylpiperidine. The title compound was obtained as a white solid (70 mg, 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168633B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-5e36d18581bc4f3d955cab9c71ec807f |
| Source note | uspto-grants-2012_05 |