HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Chloro-3-ethyl-[1,2,4]triazolo[4,3-A]pyrazine → 3-Ethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Chloro-3-ethyl-[1,2,4]triazolo[4,3-A]pyrazine | HCID 29923461 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Ethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride | HCID 67058484 | — |
Reaction Steps
The title compound was prepared from 8-chloro-3-ethyl-1,2,4-triazolo[4,3-c]pyrazine (2.70 g, 14.8 mmol, from Step A) and platinum oxide (0.4 g) in 200 mL of methanol in a paar shaker under hydrogen (50 psi) for 14 hours. Filtration through Celite followed by concentration gave the title compound as a solid. 1H NMR (500 MHz, CD3OD) δ 1.36 (t, 3H, J=6.0 Hz), 2.84 (q, 2H, J=6.0 Hz), 3.70 (t, 2H, J=8.0 Hz), 4.28 (t, 2H, J=8.0 Hz). 4.06 (s, 2H). ESI-MS 153 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168637B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-a79d72a37a184de2a557fa2f6b275483 |
| Source note | uspto-grants-2012_05 |