反应详情

A mixture of 6-(3,4-dimethoxy-benzoyl)-cyclohex-3-enecarboxylic acid (112 mg, 0.39 mmol, 1.0 eq) and hydrazine hydrate (31 mg, 0.96 mmol, 2.5 eq) in EtOH (3 mL) was refluxed for 4 hr. The reaction was then cooled to room temperature and then concentrated under reduced pressure to oil. The oil was dissolved in EtOAc and washed with water followed by brine. The organic layer was then dried over Na2SO4, filtered through paper, and concentrated under reduced pressure to oil. The product was recrystallized in EtOH to yield a white solid.

1. temperaturewas refluxed for 4 hr
2. concentrationconcentrated under reduced pressure to oil
3. dissolutionThe oil was dissolved in EtOAc
4. washwashed with water
5. dry with materialThe organic layer was then dried over Na2SO4
6. filtrationfiltered through paper
7. concentrationconcentrated under reduced pressure to oil
8. customThe product was recrystallized in EtOH
9. customto yield a white solid