Ethyl 2-aminothiazole-4-carboxylate → 2-Amino-1,3-thiazole-4-carboxamide

HRID 1919559Notes

Reaction equation

HRID 1919559 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9]CC)=O)[N:6]=1.O.[NH3:13]>>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([NH2:13])=[O:9])[N:6]=1

Participants

3

Reactant 2

HCID 73216Ethyl 2-aminothiazole-4-carboxylateHCID 12896473Azane;hydrate

Product 1

HCID 2571492-Amino-1,3-thiazole-4-carboxamideYield 76%

Procedure

3.0 g Ethyl 2-aminothiazol-4-carboxylate was added to 100 ml ammonia water, reacted for 2 hr, concentrated, and placed aside to precipitate a needle crystal, which was filtered, washed with water, and dried to obtain 1.9 g 2-aminothiazol-4-carboxamide (yield 76%) with mp 208-211° C.

Workup

  1. customreacted for 2 hr
  2. concentrationconcentrated
  3. customto precipitate a needle crystal, which
  4. filtrationwas filtered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-e8769799fc664467ac36c2aa0e09297f
Source dataset
uspto-grants-2012_05
Patent number
US08168642B2

Reaction notes

Loading…