Ethyl 2-aminothiazole-4-carboxylate → 2-Amino-1,3-thiazole-4-carboxamide

Participants

Reaction Steps

3.0 g Ethyl 2-aminothiazol-4-carboxylate was added to 100 ml ammonia water, reacted for 2 hr, concentrated, and placed aside to precipitate a needle crystal, which was filtered, washed with water, and dried to obtain 1.9 g 2-aminothiazol-4-carboxamide (yield 76%) with mp 208-211° C.

Provenance & Evidence