反应详情

g (28 mmol) 2-Aminothiazol-4-carboxamide was dissolved in 40 ml glacial acetic acid, to which added 2.8 ml (29.6 mmol) acetic anhydride, followed by reacting under reflux for 2 hr, and naturally cooling down to precipitate a large quantity of solids, which were filtered, washed and dried to obtain 4.7 g 2-acetylaminothiazol-4-carboxamide (yield 92%) with mp>250° C.

1. temperatureunder reflux for 2 hr
2. temperaturenaturally cooling down
3. customto precipitate a large quantity of solids, which
4. filtrationwere filtered
5. washwashed
6. customdried