HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-Acetylaminothiazol-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Amino-1,3-thiazole-4-carboxamide | HCID 257149 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Acetylaminothiazol-4-carboxamide | HCID 257200 | 92% |
Reaction Steps
g (28 mmol) 2-Aminothiazol-4-carboxamide was dissolved in 40 ml glacial acetic acid, to which added 2.8 ml (29.6 mmol) acetic anhydride, followed by reacting under reflux for 2 hr, and naturally cooling down to precipitate a large quantity of solids, which were filtered, washed and dried to obtain 4.7 g 2-acetylaminothiazol-4-carboxamide (yield 92%) with mp>250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168642B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-52718580884a4dfe9714e158ebcecefb |
| Source note | uspto-grants-2012_05 |