反应详情

0.35 g Ethyl 2-(2-acetylaminothiazol-4-yl)-4-(2-chloro-4-fluorophenyl)-6-methyl-1,4-dihydro-pyrimidin-5-carboxylate (Example 30) reacted with 2 ml 6 mol/L hydrochloric acid solution at 50° C. for 2 hr. The reaction product was extracted with ethyl acetate, dried, and separated by a column chromatography to obtain 0.25 g of amorphous yellow solid with mp 95-110° C.; 1H-NMR (400 MHz, DMSO-d6) δ 1.01-1.04 (3H, m); 2.39 (3H, s); 3.89-3.95 (2H, m); 5.91 (1H, br); 7.02-7.38 (6H, m, br); 8.83 (1H, br); MS (EI) 394.0 (M+).

1. extractionThe reaction product was extracted with ethyl acetate
2. customdried
3. customseparated by a column chromatography