Azane;hydrate → 2-Methylthiazole-5-carboxamide

HRID 1919573Notes

Reaction equation

HRID 1919573 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:7]([O:9]C)=O)=[CH:5][N:6]=1.O.[NH3:12]>>[CH3:1][C:2]1[S:3][C:4]([C:7]([NH2:12])=[O:9])=[CH:5][N:6]=1

Participants

3

Reactant 2

HCID 12896473Azane;hydrateHCID 21427465Methyl 2-methyl-1,3-thiazole-5-carboxylate

Product 1

HCID 233223662-Methylthiazole-5-carboxamideYield 73%

Procedure

1.4 g Methyl 2-methylthiazol-5-carboxylate was added to 25 ml ammonia water, to carry out reaction at room temperature for 3 hr. The reaction product was cooled down, filtered, and washed with water to obtain 0.95 g a white powdery solid (73%) with mp 202-205 (C.

Workup

  1. customreaction at room temperature for 3 hr
  2. temperatureThe reaction product was cooled down
  3. filtrationfiltered
  4. washwashed with water

Sources & evidence

ORD record
ord-c38b706d80a24896bfb56f94447db64e
Source dataset
uspto-grants-2012_05
Patent number
US08168642B2

Reaction notes

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