Acetic Anhydride → HCID 20544504, compound

HRID 1919575Notes

Reaction equation

HRID 1919575 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:7]#[N:8])=[CH:5][N:6]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>C(O)(=O)C>[C:9]([NH:1][C:2]1[S:3][C:4]([C:7]#[N:8])=[CH:5][N:6]=1)(=[O:11])[CH3:10]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 100575072-Aminothiazole-5-carbonitrile

Product 1

HCID 20544504HCID 20544504, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2.14 g 2-Amino-5-cyanothiazole was dissolved in 10 ml acetic acid, and 1.8 ml acetic anhydride was added to carry out reaction at 100° C. for 30 min. The reaction product was cooled down, and filtered to obtain 2.5 g of a clay-solid having metallic luster (yield 80%), 1H NMR (DMSO-d6) 2.22 (3H, s), 8.36 (1H, s), 12.95 (1H, s).

Workup

  1. customreaction at 100° C. for 30 min
  2. temperatureThe reaction product was cooled down
  3. filtrationfiltered

Sources & evidence

ORD record
ord-47e75d2f864c491e925dee59704ce60e
Source dataset
uspto-grants-2012_05
Patent number
US08168642B2

Reaction notes

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