Hydrochloric Acid → HCID 24810503, compound

Participants

Reaction Steps

Ethyl 2-(2-acetylaminothiazol-5-yl)-4-(2-chloro-4-fluorophenyl)-6-methyl-1,4-dihydro-pyrimidin-5-carboxylate (Example 43) was refluxed with 6 mol/L HCl in ethanol to obtain 0.15 g a yellowish solid with mp 132-135° C.; 1H-NMR (400 MHz, DMSO-d6) δ 1.0-1.05 (3H, m); 2.50 (3H, s); 3.90-3.93 (2H, m); 5.82 (1H, s); 7.13-7.50 (5H, m); 7.69 (1H, s); 9.19 (1H, s); MS (EI) 394.0 (M+).

Provenance & Evidence