Hydrochloric Acid → HCID 24810503, compound

HRID 1919577Notes

Reaction equation

HRID 1919577 reaction equation
C([NH:4][C:5]1[S:6][C:7]([C:10]2[NH:11][C:12]([CH3:29])=[C:13]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH:14]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[Cl:23])[N:15]=2)=[CH:8][N:9]=1)(=O)C.Cl>C(O)C>[NH2:4][C:5]1[S:6][C:7]([C:10]2[NH:11][C:12]([CH3:29])=[C:13]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH:14]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[Cl:23])[N:15]=2)=[CH:8][N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24810557HCID 24810557, compound

Product 1

HCID 24810503HCID 24810503, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-(2-acetylaminothiazol-5-yl)-4-(2-chloro-4-fluorophenyl)-6-methyl-1,4-dihydro-pyrimidin-5-carboxylate (Example 43) was refluxed with 6 mol/L HCl in ethanol to obtain 0.15 g a yellowish solid with mp 132-135° C.; 1H-NMR (400 MHz, DMSO-d6) δ 1.0-1.05 (3H, m); 2.50 (3H, s); 3.90-3.93 (2H, m); 5.82 (1H, s); 7.13-7.50 (5H, m); 7.69 (1H, s); 9.19 (1H, s); MS (EI) 394.0 (M+).

Sources & evidence

ORD record
ord-b3baed06ef014b6ab45502ff23aafbf8
Source dataset
uspto-grants-2012_05
Patent number
US08168642B2

Reaction notes

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