Hydrochloric Acid → HCID 57500677, compound

HRID 1919656Notes

Reaction equation

HRID 1919656 reaction equation
C([NH:4][C:5]1[S:6][C:7]2[C:16]3[CH:15]=[CH:14][C:13]([C:17]([OH:19])=[O:18])=[CH:12][C:11]=3[NH:10][C:9](=[O:20])[C:8]=2[N:21]=1)(=O)C.Cl>O>[NH2:4][C:5]1[S:6][C:7]2[C:16]3[CH:15]=[CH:14][C:13]([C:17]([OH:19])=[O:18])=[CH:12][C:11]=3[NH:10][C:9](=[O:20])[C:8]=2[N:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57500676HCID 57500676, compound

Product 1

HCID 57500677HCID 57500677, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-acetamido-4-oxo-4,5-dihydrothiazolo[4,5-c]quinoline-7-carboxylic acid (102 mg, 0.34 mmol) was stirred at 120° C. in aqueous 6N HCl overnight. Water was added and the compound was filtered and dried to provide 2-amino-4-oxo-4,5-dihydrothiazolo[4,5-c]quinoline-7-carboxylic acid as a black solid (76 mg, 86% yield). LCMS (ES): 95% pure, m/z 262 [M+1]+, 1H NMR (DMSO-d6, 400 MHz) δ 7.60 (d, J=8.4, 1H), 7.70 (dd, J=1.2, J=8.0, 1H), 7.99 (d, J=1.2, 1H), 11.94 (s, 1H) ppm.

Workup

  1. filtrationthe compound was filtered
  2. customdried

Sources & evidence

ORD record
ord-06b33967ebf1481180b8803f39bf7d95
Source dataset
uspto-grants-2012_05
Patent number
US08168651B2

Reaction notes

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